Estrogen response element binding induces alterations in estrogen receptor-alpha conformation as revealed by susceptibility to partial proteolysis
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چکیده
منابع مشابه
Mouse Estrogen Receptor b Forms Estrogen Response Element- Binding Heterodimers with Estrogen Receptor a
The recent discovery that an additional estrogen receptor subtype is present in various rat tissues has advanced our understanding of the mechanisms underlying estrogen signaling. Here we report on the cloning of the cDNA encoding the mouse homolog of estrogen receptor-b (ERb) and the functional characterization of mouse ERb protein. ERb is shown to have overlapping DNA-binding specificity with...
متن کاملDifferential Response of Estrogen Receptor a and Estrogen Receptor b to Partial Estrogen Agonists/Antagonists
The existence of two rather than one estrogen receptor, today characterized as estrogen receptor a (ERa) and estrogen receptor b (ERb), indicates that the mechanism of action of 17b-estradiol and related synthetic drugs is more complex than previously thought. Because the homology of amino acid residues in the ligand-binding domain (LBD) of ERb is high compared with those amino acid residues in...
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In addition to classical genomic mechanisms, estrogen also exerts nonclassical effects via a signal transduction system on neurons. To study whether estrogen has a nonclassical effect on basal forebrain cholinergic system, we measured the intensity of cAMP response element-binding protein (CREB) phosphorylation (pCREB) in cholinergic neurons after administration of 17beta-estradiol to ovariecto...
متن کاملThe high mobility group protein 1 enhances binding of the estrogen receptor DNA binding domain to the estrogen response element.
We have examined the ability of the high-mobility group protein 1 (HMG1) to alter binding of the estrogen receptor DNA-binding domain (DBD) to the estrogen response element (ERE). HMG1 dramatically enhanced binding of purified, bacterially expressed DBD to the consensus vitellogenin A2 ERE in a dose-dependent manner. The ability of HMG1 to stabilize the DBD-ERE complex resulted in part from a d...
متن کاملEstrogen receptor alpha polymorphism and susceptibility to uterine leiomyoma.
Uterine leiomyoma is the most frequent pelvic tumor found in female genital tract. Some studies have suggested an association between single nucleotide polymorphisms (SNPs) in estrogen receptors genes with susceptibility in developing uterine leiomyoma. In this work, we estimated the frequency of two SNPs: one located in the intron 1 (rs9322331) and other in the exon 1 (rs17847075) of the estro...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2001
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme.0.0270275